TL;DR 

  • Topical PDRN (e.g. creams/serums) supports daily skin repair and maintenance, but due to its large molecular size, it works only on the skin’s surface.
  • Injectable PNDR (e.g. Rejuran) delivers concentrated PDRN deep into the dermis for faster, targeted results—ideal for scars, ageing, and deeper concerns.
  • A hybrid approach (regular Rejuran + daily PDRN skincare) offers the best of both worlds: immediate rejuvenation and long-term skin health.

Table Of Contents

With the rise of medical-grade skincare and patients becoming more proactive about their routines, many are hoping to find needle-free alternatives to in-clinic procedures.

Plus, with popular brands like Rejuran launching their own skincare lines, it’s no surprise we’re all wondering the same thing: Can topical PDRN treatments replace injectables?

Let’s explore whether PDRN skincare is truly a replacement—or more of a powerful companion—to Rejuran injections.

What is PDRN, and How Does It Work in Skincare?

PDRN stands for Polydeoxyribonucleotide—a naturally derived compound from salmon DNA. While that might sound rather unglamorous, its regenerative abilities are remarkable.

So, how does PDRN work?

  • Collagen & Healing Boost: PDRN activates the adenosine A2A receptor in the skin, which triggers a biological cascade that enhances collagen production and speeds up tissue repair.
  • Angiogenesis* Promotion: It upregulates our vascular endothelial growth factor (VEGF), stimulating the formation of new blood vessels—crucial for oxygenation, nutrient delivery, and overall skin healing.
  • Pigment Regulation: PDRN inhibits melanin production in a dose-dependent manner, helping to improve pigmentation issues and even skin tone.

*Angiogenesis is the process by which new blood vessels are formed from existing ones. It is vital because it forms new blood vessels that boost circulation and nutrient delivery, accelerating healing, enhancing treatment effects, and improving overall skin radiance.

​Polydeoxyribonucleotide (PDRN) therapy offers several notable benefits for skin health:

  • Anti-Ageing Effects: PDRN therapy can reverse signs of ageing by reducing fine lines and wrinkles, leading to a more elastic and firm skin texture. ​
  • Collagen Production: It promotes collagen synthesis, which is crucial for maintaining skin elasticity and reducing the appearance of ageing.
  • Tissue Repair and Healing: PDRN enhances tissue repair and healing processes, contributing to skin rejuvenation. ​
  • Anti-Inflammatory Properties: It possesses anti-inflammatory properties, which can help soothe and calm the skin. ​
  • Angiogenesis: PDRN promotes angiogenesis, the formation of new blood vessels, which is beneficial for skin health and regeneration.

While PDRN offers impressive regenerative properties, its relatively large molecular size means topical absorption can be limited—making long-term efficacy somewhat debatable. 

Therefore, many PDRN skincare products are paired with peptides, growth factors, or hyaluronic acid to enhance penetration and boost results.

With consistent use, topical PDRN may support skin rejuvenation, hydration, and repair—though results tend to be more gradual than injectables.

Injectable PDRN, such as Rejuran, remains more scientifically validated, but we still need more independent clinical studies to understand the long-term benefits of topical PDRN use.

That said, PDRN skincare can be highly effective as part of a holistic routine, especially when combined with synergistic in-clinic treatments.

Rejuran vs PDRN Skincare: Understanding the Difference

It’s easy to conflate the two since Rejuran is essentially a PDRN-based injectable. However, when comparing PDRN skincare and Rejuran Injection, the distinction lies in depth, speed, and concentration.

Aspect

PDRN Skincare

Rejuran Injection

Penetration

Limited to superficial skin layers

Delivered directly into the deeper dermis

Results Timeline

Gradual with consistent use

Faster, with visible changes in weeks

Intensity

Gentle and suitable for daily use

More intense, clinical-level treatment

Customisation

Generalised for whole-face use

Targeted injections for specific concerns

Side Effects

Minimal (e.g. mild irritation)

Possibility of bruising, swelling

One study comparing topical vs injectable PDRN found both beneficial for wound healing, though the injectable form demonstrated more significant effects—particularly for deeper issues like scarring.

It’s also worth noting that Rejuran Healer*, the most popular injectable variant of Rejuran in Singapore, has a higher viscosity and concentration of PDRN than any cream can offer. 

When injected precisely under scars or lines where topical products can’t reach, injectable PDRN can offer much more concise and significant results.

*There are three types of Rejuran available in Singapore:

  • Rejuran I – Low viscosity; ideal for delicate under-eye areas and fine lines.
  • Rejuran Healer – Medium viscosity; boosts hydration and regeneration for full-face and neck rejuvenation.
  • Rejuran S – High viscosity; best for acne scars, acting like a filler for depressed or sunken areas.

You might be interested in The Different Types of Rejuran in Singapore.

Who Is PDRN Skincare Suitable For?

PDRN skincare (creams, serums) is ideal for those who want to gently enhance their skin health over time, especially if:

  • You are already undergoing treatments (e.g. lasers, injectables) and would like to enhance your results
  • Want daily skin maintenance to support in-clinic results
  • Struggle with superficial signs of ageing like fine lines and enlarged pores

We recommend a hybrid approach—Monthly Rejuran injections for deeper repair and rejuvenation, paired with regular PDRN skincare to maintain and enhance results at home. 

This layered strategy gives you the immediacy of clinical results and the long-term added nurture of daily care.

Needleless Rejuran: Is It Just PDRN Cream in Disguise?

You may have come across needleless Rejuran options—often via transdermal devices or PDRN-infused facials. While needleless Rejuran may contain similar ingredients, they are not equivalent to Rejuran Healer injections.

Needleless versions can be helpful for:

  • Mild acne and/or dullness
  • Dehydrated skin
  • Light pigmentation
  • Surface-level textural concerns

But if your goals include treating deep acne scars, prominent pores, or fine lines, then only a Rejuran Injection can reach the dermis to target and treat these issues. As doctors, we also inject Rejuran selectively into problematic areas—such as directly under a depressed scar—which no needleless method can do.

Think of it this way: PDRN skincare is like feeding your skin a nourishing diet, while Rejuran injections are more akin to delivering vitamins via an IV drip—highly targeted, concentrated, and faster-acting.

Can PDRN Skincare Replace Rejuran Injections?

In short, no, but it can beautifully complement them.

PDRN skincare, including Rejuran Skincare products, is beneficial for maintaining skin health, reducing inflammation, and supporting ongoing collagen synthesis. However, when it comes to deeper skin issues, Rejuran injections remain the undisputed choice.

That said, not every patient needs Rejuran. If you’re in your 20s or early 30s, have no major skin concerns, or prefer to avoid injections, PDRN skincare is a fantastic alternative. Just set realistic expectations—results will be slower and more subtle, and you won’t be able to target deeper issues.

If you’re in your late 30s and beyond or dealing with specific issues like scars or ageing, Rejuran in Singapore continues to be one of our most trusted and practical solutions—and with good reason.

Conclusion: The Best of Both Worlds

In the ever-evolving landscape of aesthetic medicine, we’re lucky to have both topical and injectable solutions like PDRN skincare and Rejuran Healer. They each serve unique roles and, when used together, can holistically transform the way we care for our skin.

The beauty of injectable Rejuran lies in its precision. Each formulation—Rejuran I for the under-eyes, Rejuran Healer for overall rejuvenation, or Rejuran S for acne scars—has a specific viscosity and concentration designed for a particular depth and concern. Doctors can deliver the product exactly where needed, such as just beneath a wrinkle or under a depressed scar, with control over both placement and dosage.

Even the best PDRN skincare products only work on the surface. The skin’s barrier naturally limits how deeply ingredients can penetrate, which means topicals are more general in their effect—they cannot nourish the skin as profoundly or precisely.

As always, speak with a doctor who understands your skin concerns and goals before deciding on a treatment path. Whether you’re looking to dip your toes into anti-ageing or ready for more intensive rejuvenation, we’re here to help guide the way.

Book an appointment today with SL Aesthetic Clinic for more information.