The cysteamine whitening cream uses the active ingredient cysteamine, the simplest natural aminothiol produced in human cells – a metabolite of amino acid L-cysteine.
Cysteamine promotes the transport of L-cysteine into human cells. This can be further used to synthesise Glutathione, an antioxidant. Cysteamine inhibits melanin (dark pigment) synthesis in skin cells, therefore reducing pigmentation.
Initially, oral Cysteamine was approved by the U.S. Food and Drug Administration for human use for cystinosis, a rare genetic disorder. However, research has found that Cysteamine has significant de-pigmenting activity such as in melasma.
But despite this, it has never been formulated into a cream due to its unpleasant sulphur odour. Efforts have enabled a stabilised form of a cysteamine whitening cream with reduced odour.
The cysteamine whitening cream has been shown to be effective for:
Clinical studies have shown Cysteamine Cream to be superior to traditional depigmenting creams such as Hydroquinone in treating melasma.
It is also safer and gentler on human skin due to the fact that it is naturally occurring in human skin cells, and does not have carcinogenic (cancer-causing) potential in long-term use.
Cysteamine Cream can be applied any time of the year regardless of sun exposure and is suitable for all skin tones.
The cream is applied to the desired areas with pigmentation once daily and is washed off after 15 minutes using mild soap and water. After drying the skin, a moisturizer is applied.
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A reduction in pigmentation is seen after 6 weeks. Optimal results are seen after 8 – 12 weeks.
As Cysteamine is naturally occurring in human cells, it is a very safe medication. It may cause temporary burning sensation or redness that goes away within 30 minutes.
More persistent skin irritation should be treated with moisturisers. To date, no serious adverse side effects have been reported with Cysteamine use.
Cysteamine Cream should not be used in those with a personal or family history of Vitiligo, a depigmenting skin disorder. It should also not be used by pregnant or breastfeeding women, as no study has been performed during pregnancy or breastfeeding.