TL;DR 

  • Juvelook: Combines hydration and collagen boost.
  • Rejuran: Focuses on cellular repair and regeneration.
  • Plinest: Enhances collagen and elastin production.
  • Profhilo: Targets hydration and skin firmness.

In the skincare world, skin boosters have become a game-changer for those looking to rejuvenate their appearance without invasive procedures, or downtime.

As the market continues to evolve, new names like Juvelook and Plinest have emerged. 

Confused about the differences between these injectables? 

This article looks at the most common skin boosters today, such as Juvelook, Rejuran, Profhilo, and Plinest.

What is a Skin Booster?

Skin boosters are biological materials or bio-actives that help the skin to increase or improve its functions. Often, it also implies an injectable form of application.

The main functions of skin boosters are: 

  • Hydration: Increasing the skin’s moisture levels.
  • Improving Skin Quality: Enhancing skin texture and elasticity.
  • Non-Invasive Rejuvenation: Restoring youth sans surgeries.

Restylane was the first to utilise the term skin booster when it released its SKINBOOSTERS range of HA-based injectables. Over time, the term grew to include other biological materials such as polynucleotides, amino acids and many other bioactive compounds.

Is Juvelook a Skin Booster?

Derived from the Latin word for youth (juve), Juvelook is a hybrid skin booster that helps patients achieve a youthful-looking appearance and combat the signs of ageing.

As a hybrid skin booster, Juvelook integrates two key components:

  1. Hyaluronic Acid (HA): Provides immediate hydration and plumpness to the skin. HA is considered the conventional skin booster.
  2. Poly DL-lactic Acid (PDLLA): Stimulates long-term collagen production, helping to improve skin structure and reduce signs of ageing over time.

Right after Juvelook treatment, patients experience an immediate plumping effect, and those with mild to moderate wrinkles or fine lines may notice smoother and younger-looking skin.

Those with acne scars may also see improvement—Juvelook PDLA treatment is recommended as a component of acne scar treatment. 

Comparing Juvelook with Rejuran, Profhilo, and Plinest

Rejuran

Rejuran is a polynucleotide-based treatment that uses DNA fragments to stimulate skin rejuvenation.

  • How It Works: Rejuran contains polynucleotides (PN)* that enhance cellular repair and promote collagen production. The DNA fragments support skin regeneration and repair.
  • Benefits:
    • Stimulates the skin’s natural regeneration
    • Improves skin density & elasticity
    • Promotes skin repair

There are three types of Rejuran treatments available:

  • Rejuran I – Has a lower viscosity than the other Rejuran formulations, making it ideal for getting rid of wrinkles around the eyes and general under-eye rejuvenation.
  • Rejuran Healer – Has a medium viscosity level and can provide added hydration, which helps strengthen the skin’s regenerative ability. Ideal for full-face and neck rejuvenation.
  • Rejuran S – Has the highest viscosity and is ideal for acne scar treatment, acting like a filler for depressed and sunken spots.

*Polynucleotides (PN) are the building blocks of DNA and are commonly derived from fish like trout or salmon. Rejuran extracts PN from Salmon, whereas Plinest harvests PN from Trout.

Also Read: Types of Rejuran: Which Works Best For You

Rejuran’s formula uses polynucleotides to stimulate collagen and elastin production and promote skin repair at a cellular level, making it a targeted solution for achieving skin firmness and elasticity. It does not focus on drawing water into the dermis to improve the skin’s hydration levels.

Juvelook also promotes collagen production, but by combining HA with PDLLA,it offers more immediate skin hydration

In summary, While Juvelook offers a versatile combination of hydration and collagen stimulation, Rejuran may be better suited for those specifically looking to enhance skin health at a cellular level.

Plinest

Plinest, like Rejuran, is also based on polynucleotides. It shares several similarities with Rejuran but has some distinct features:

  • How It Works: Uses polynucleotides from trout to rejuvenate the skin by boosting collagen and elastin production.
  • Benefits:
    • Cellular Repair: Plinest encourages damaged skin cells to repair themselves. As we age, our skin invariably ages and experiences a loss of normal skin function. Plinest helps to restore these cells to their optimal state while improving your skin’s overall appearance.
    • Hydration: One of the standout effects of Plinest skin booster treatment is that it boosts skin hydration and elasticity. It attracts moisture, helping your skin retain essential hydration for a plump and youthful appearance.
    • Skin barrier restoration: Plinest also stimulates the repair of your skin’s natural barrier, preventing redness, itch and irritation.

Profhilo

Profhilo is a popular treatment that uses a high concentration of hyaluronic acid to boost and hydrate skin while remodelling ageing and sagging tissue:

  • How It Works: Profhilo’s unique formulation of hyaluronic acid allows it to integrate seamlessly into the skin, providing deep hydration and improving skin firmness.
  • Benefits:
    • High HA concentration: One of the highest concentrations of HA on the market (64mg/2ml).
    • Hydration: Delivers high levels of moisture to the skin.
    • Firmness: Enhances skin elasticity and reduces sagging.
    • Suitability: Particularly effective for addressing skin laxity and providing a hydration boost.

While both Juvelook and Profhilo are effective in enhancing skin hydration and elasticity, there are key differences.

Profhilo uses a higher concentration of hyaluronic acid for more intense hydration and helps combat volume loss by stimulating skin remodelling to restore skin elasticity and firmness using its patented NAHYCO® technology, while Juvelook uses PDLLA for long-term collagen stimulation, and HA for improving skin hydration levels.

Also Read: What are the Conditions that Profhilo Treatment in Singapore Treats?

Another key difference is that Profhilo is delivered to the skin using the 5 bio-aesthetic point technique, allowing even spread of the product with just 5 strategic injection points for each half of the face, whereas Juvelook is delivered using microinjections – multiple tiny injections throughout the areas of concern.

To sum it up, here is a table comparing the unique aspects of the treatments mentioned: 

FeatureJuvelookRejuranProfhiloPlinest
Key IngredientsPoly D L-lactic Acid (PDLLA) + Hyaluronic Acid (HA)Polynucleotides (PNs)High-Concentration Hyaluronic Acid (HA)Polynucleotides (PNs)
FocusImmediate hydration + collagen stimulationCellular repair and regenerationDeep hydration + Skin firmnessCollagen and elastin production to repair damaged skin and reverse signs of ageing
MechanismHydrates skin immediately and stimulates long-term collagen with PDLLAStimulates cellular repair and fibroblast activity for collagen productionIntegrates into the skin to provide deep hydration and stimulates collagen production to enhance firmnessStimulates collagen and elastin production, improving skin density and texture
TechniqueMicroinjectionsMicroinjections5 bio-aesthetic point techniqueMicroinjections or cannula (strategic entry points, usually three, on the skin to deliver the product throughout the face)
ResultsEnhances hydration, texture, and elasticity with long-term collagen stimulation, but does not focus on cellular regeneration.Improves skin texture, firmness, and resilience through natural regenerationEnhances hydration, gives a natural lift to the skin and improves skin firmness.Improves skin texture, and elasticity, reduces redness and sensitivity, faster skin recovery.
Treatment for Damaged SkinProvides hydration and collagen stimulation, which may not address deeply damaged skin as effectivelyEffective for repairing damaged or ageing skin through cellular repairIdeal for treating skin laxity and hydration issues, less focus on repairEffective for improving skin density and texture, especially for ageing skin
Suitable forImmediate hydration and sustained collagen stimulationComprehensive skin rejuvenation, particularly for damaged or ageing skinAddressing skin laxity and providing a hydration boostReversal of damaged, sensitive and ageing skin

Conclusion

While Juvelook is a notable hybrid addition to the skin booster market, treatments like Rejuran, Plinest, and Profhilo offer specialised benefits that may better suit your skincare needs.

By understanding the unique advantages of each treatment, you can make an informed decision about the best approach for achieving youthful, radiant skin.

For a personalised consultation and to explore the best options for your skincare goals, talk to us to learn more about Rejuran, Plinest, and Profhilo. We are here to help you find the most effective solution for your needs!