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Your guide to Plinest treatment in Singapore |
PN Skinbooster for Radiant, Glowy Skin

If you want to rediscover your skin’s youthful glow, Plinest® could be the key to unlocking the radiant complexion you desire. Thanks to its impressive results, this skin booster treatment has emerged as a popular solution for skin rejuvenation.

Plinest® is packed with a regenerative ingredient known as polynucleotides (PN), naturally occurring DNA molecules that can reverse the signs of ageing.

In this guide, we will share more about Plinest® treatment, exploring how it works, the benefits it offers, and why it has gained popularity among men and women in Singapore seeking to revitalise their skin.

What is Plinest treatment?

Plinest Treatment Singapore

Plinest® is a type of skin booster treatment designed to rejuvenate your skin from within. Similar to Rejuran, it utilises a powerful and natural regenerative ingredient known as polynucleotides (PN).

PN are a type of DNA molecule that occurs naturally. However, unlike Rejuran PN, which is sourced from salmon, PN in Plinest are sourced from the reproductive glands of trout fish and then meticulously purified using a patented Highly Purified Technology (HPT). This unique and natural origin of the active ingredient is what sets Plinest® apart from many other skincare solutions.

Plinest skin booster treatment provides a host of benefits, such as:

  • Restoring a youthful appearance
  • Rejuvenating skin from the inside out
  • Firming, tightening and lifting the skin
  • Restoring skin volume
  • Improving scalp hair growth
  • Minimal downtime

Plinest® was created using HPT™ technology and certified with the European Union CE mark since 2005. It is compatible with the human body. 

Also Read: Fotona Fractional Erbium Laser for Acne Scars

How does Plinest work?

Once injected into the skin, PN stimulates a cascade of regenerative processes. They prompt your body’s fibroblast production to increase collagen, through the following ways:

Cellular repair

PN encourages damaged skin cells to repair themselves. As we age, our skin invariably suffers from sun exposure, pollution, or various other factors. This results in not just the outward appearance of ageing, but also a loss of normal skin function. Plinest® can help restore these cells to their optimal state, improving both your skin’s appearance and function

Hydration and elasticity

One of the standout benefits of Plinest® skin booster treatment is that it boosts skin hydration and elasticity. It attracts moisture, helping your skin retain essential hydration for a plump and youthful appearance.

Natural barrier restoration

A compromised skin barrier can lead to various skin issues, including sensitivity and redness. As Plinest aids your skin in cellular repair and regeneration, it also stimulates the repair of your skin’s natural barrier, making it more resilient against external irritants.

What can Plinest treat?

Dull and dry skin

Environmental factors, ageing, and lifestyle choices can leave your skin looking dull and feeling dry. Plinest® revitalises your skin by improving hydration, leaving it radiant and supple.

Sensitive skin

Sensitive skin requires special care, and Plinest® is gentle yet effective. It helps repair the skin’s barrier, reducing sensitivity and redness while enhancing your skin’s resilience.

Fine lines and wrinkles

Plinest® skin booster treatment  reduces the appearance of fine lines and wrinkles by promoting skin hydration, collagen production and skin revitalisation. It is clinically proven to reduce superficial lines and wrinkles in over 91% of patients, based on a physician assessment.

Enlarged pores

Enlarged pores are a common concern in Singapore, especially in areas like the nose and cheeks. Plinest® skin booster treatment can help refine the appearance of pores, giving your skin a smoother texture.

Hair Loss

Plinest® can be combined with various hair loss treatments to improve the scalp environment and encourage hair growth. Polynucleotides in Plinest® limit the impact of hormones on hair follicles while promoting cell regeneration. By itself, Plinest® has been shown in multiple clinical studies to be especially effective for over 72% of women with female pattern hair loss. It also works for male pattern hair loss, and patients overall observe highly satisfactory results with a marked reduction in hair loss and no side effects.  


Acne scars

Acne scars can make you feel self-conscious. Plinest® promotes the regeneration of skin tissue, gradually diminishing the appearance of acne scars for smoother and more even skin.


Hyperpigmentation can be challenging to address. Plinest® aids in promoting a more even complexion by encouraging cell renewal and reducing the appearance of dark spots.

Volume loss

Losing facial volume is a part of the ageing process. Plinest® can help restore volume to thinned or sagged areas, giving your face a youthful contour.

Can Plinest be combined with other treatments?

As Plinest is a versatile treatment with minimal downtime, it can be seamlessly incorporated into most of your aesthetic treatment regimes. Combining Plinest with treatments such as laser therapy, RF gold microneedling, dermal fillers, chemical peels, and Botulinum Toxin Type A (BTA) injections can improve the overall treatment outcomes.

Is Plinest treatment painful?

Plinest treatment is a very well tolerated procedure. Adequate numbing cream will be applied to ensure you feel comfortable throughout. During the treatment, we have various methods such as a vibrating device and ice packs to further lessen the discomfort, if necessary.


How much does Plinest treatment cost?

The price of Plinest® skin booster treatment in Singapore typically starts at $900.  However, the final price may vary depending on the extent of the treatment area, the number of sessions required, and the specific goals you have in mind.

Plinest treatment can be a friendly option for those seeking a subtle yet effective treatment in overall skin rejuvenation. It provides a cost-effective option for achieving a more youthful and radiant complexion without the downtime and expense associated with surgical procedures.

Please book a consultation with us for a personalised assessment and pricing estimate. We can evaluate your unique skin concerns and draw out a treatment plan tailored to your needs and budget.



Results with Plinest may last up to one year, after completing a recommended course of treatment

We recommend two to three sessions spaced about one month apart for the best results.

Plinest can be used tofor treat and rejuvenate the face, neck, scalp, hands and decollete.

Newest is a unique polynucleotide-based skin booster treatment like Plinest. The main difference is that Newest contains hyaluronic acid, which has a hydrating and volumising effect. 

There is minimal downtime and you can resume your regular activities after. There might be mild bruising and swelling at the injection site but they should subside within a few days. 

The procedure takes between 15-20 minutes.


  • Avoid alcohol and prolonged sun exposure.


  • Touching or rubbing the treated area 
  • Strenuous physical activity for the next 24 hours 
  • Drinking alcohol for the next 24 hours 
  • Hot saunas, hot showers or other forms of heat exposure for the next 24 hours
  • Prolonged sun exposure for the next 24 hours

Collagen stimulation and skin hydration is an ongoing process – generally you should observe visible results a week after treatment, and results will continue to improve over the next few weeks, especially with maintenance treatments. 

Yes, Plinest can be combined with other treatments including injectables and energy-based devices. A combination treatment approach would often yield better results. 

Both Plinest and Rejuran are polynucleotide gels and skinboosters that improve overall skin health. The key difference between both is that Plinest is extracted from Italian trout fish, while Rejuran from salmon. Plinest also does not contain hyaluronic acid, unlike Rejuran. 

Yes, Plinest is CE certified and backed by 70 years of research. It also utilises Mastelli’s HPT (highly purified technology) and is very compatible with human skin.

Clinical studies confirm that when injected on the scalp, Plinest encourages trophic stimulation and promotes hair growth, especially in cases of female pattern hair loss. Plinest hair loss treatment is a safe, effective and non-invasive treatment for patients. 

Plinest is also equally effective for men. In fact, it is useful as an adjuvant post FUE hair transplant. 

Note: Plinest Hair is not available in Singapore. We use Plinest Fast to treat hair loss, in which product ingredients are the same as Plinest Hair. 

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