Our outlets will be closed from 26 Mar (Tue) to 27 Mar (Wed) for our annual team bonding event. We will resume operations on 28 Mar (Thu).
Our outlets will be closed from 26 Mar (Tue) to 27 Mar (Wed) for our annual team bonding event. We will resume operations on 28 Mar (Thu).

Topical Acne Cream (Aklief Singapore)

Topical Acne Cream (Aklief Singapore) ​

Acne treatment at SL Aesthetic Clinic runs the gamut, from acne lasers, Ethosome Gold PTT to oral medication. Aklief treatment, a topical medication, is one of them. 

What Is Aklief (Trifarotene)?

Aklief is a topical acne medication used to treat acne on the face, chest, shoulders and back. It contains the retinoid trifarotene, which affects the growth of cells, prevents the formation of new acne and reduces inflammation associated with acne and pimples. 

How Does Aklief Work?

Aklief contains trifarotene, a 4th generation retinoid that works to specifically target RAR-y, a retinoic acid receptor in the skin. Doing so can: 

  • Target acne-causing bacteria
  • Replace old skin cells 
  • Exfoliate old skin cells
  • Prevent new acne from developing 

In clinical studies, Aklief (trifarotene) has been shown to demonstrate improved tolerability compared with existing topical retinoids such as differin and epiduo. It is the first retinoid approved by the U.S FDA to treat acne, and also the only retinoid approved to treat truncal acne.  

How Soon Can I See Results With Aklief Acne Cream?

In clinical trials, participants showed improvements in their facial acne in as soon as 2 weeks – but individual results vary and your doctor would be able to advise better. 

What Are The Benefits Of Aklief?

  • Easy to apply cream 
  • Suitable for a wide group of people, including teenagers (Aklief is safe for use in patients 9 years and older)
  • No need for oral medication 
  • Treats acne on the face, chest, shoulders, and back 
  • Suitable for sensitive skin 

Apart from the obvious acne benefits, since Aklief contains a retinoid, users of this product can also reap the benefits of using retinoids such as; 

  • Increased collagen levels in the skin
  • Smoother and healthier skin 
  • Reduced clogged pores
  • Reduced fine lines and wrinkles 

However, please take note that Aklief is after all still an acne treatment, so its purpose of use should still be for acne. If you are interested in improving skin texture, our friendly team can recommend focused treatments. 

What Are The Side Effects Of Aklief?

The most common side effects associated with Aklief are site irritation, itching, and sunburn. These side effects are likely to happen during the first 4 weeks of treatment – this is normal as your skin gets used to the product. 

To reduce your risk of developing side effects, moisturise your skin as much as possible when you are on Aklief skin treatment. During treatment, you should also: 

  • Minimise exposure to sunlight 
  • Avoid using tanning beds
  • Always apply sunscreen 
  • Avoid using medicated or abrasive soaps 
  • Avoid using soaps or skincare products that dry your skin 
  • Avoid using products that contain high amounts of alcohol


Contact Us


Aklief cream is suitable for patients 9 years and older.
No, Aklief should avoid contact with the eyes, lips, mouth, corner of the nose and vagina.
In Singapore, Aklief is a prescription medication that can only be prescribed by a doctor.
With every acne treatment, there is always a risk that your acne can come back. This does not mean that the treatment did not work; but pores can become clogged again, causing acne to reappear. Your doctor should be able to advise accordingly.

Aklief can help reduce blackheads and whiteheads, or comedonal acne.

Yes, Aklief is approved by the FDA to treat acne. Trifarotene, the active ingredient in Aklief, is the first topical retinoid molecule to receive FDA approval for treating acne in 20 years.

Both Aklief and WINLEVI are topical medication for acne. The main difference is Aklief’s main ingredients is trifarotene, a retinoid that unclogs pores; while WINLEVI contains clascoterone, an antiandrogen that targets acne-causing hormones. WINLEVI is not available in Singapore. 

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